Pomegranate extract
Pomegranate Extract in Prostadine: The PSA Study in Context
Pomegranate extract for prostate support has no trial in men with an enlarged prostate. The best-known studies tested juice or extract in men with rising PSA after prostate cancer treatment, and neither had a placebo group. Prostadine lists pomegranate sixth of nine ingredients and prints no amount, so the studies cannot be matched to the bottle.
Written by the Prostadine label deskUpdated
The fruit01
What does pomegranate extract do for the prostate?
Nobody has shown that it does anything for an enlarged prostate. The research is about something else.
Pomegranate is a fruit rich in plant compounds called polyphenols. The Prostadine sales page lists pomegranate extract sixth of nine ingredients and gives it two claims, "Maintains healthy blood flow" and "Supports testosterone levels" (Prostadine sales page).
The prostate shows up in pomegranate research for one reason. Doctors follow PSA, a blood marker, after cancer treatment, and a few small studies watched whether pomegranate changed how fast it rose. That is a question about cancer follow-up, not about the weak stream or night trips that BPH causes (NIDDK, Enlarged Prostate (BPH)).
The sales page does not print how much extract is in 2 ml. The table lists what the label desk can say.
| Name on the sales page | Pomegranate Extract |
|---|---|
| What it is | Punica granatum fruit |
| Group | Plant extracts |
| Amount in 2 ml of Prostadine | Not printed |
| What the sales page claims | “Maintains healthy blood flow” / “Supports testosterone levels” |
| What the evidence says | Small, uncontrolled PSA studies; no proof of prostate benefit |
| Known or traditional use | Polyphenol-rich fruit |
| Main caution | Juice may change levels of some medicines, such as warfarin. |
Study one02
What did the PSA doubling-time study find?
In men with rising PSA after cancer treatment, daily juice went with a slower rise. The study had no comparison group.
PSA doubling time is how long the number takes to double. A longer time can mean slower progress, but the number is only a marker. In the juice study, men drank 8 ounces a day, and the average doubling time went from 15 months to 54 months (Pantuck et al., Clin Cancer Res 2006).
The authors said the results "warrant further testing" in a placebo-controlled study. They did not say juice slows cancer. No one in the study was compared with a man who drank something else.
The study used a drink, in men who already had prostate cancer. Prostadine is a liquid extract for general prostate and urinary support, so the finding does not carry over to it.
Study two03
Why is the uncontrolled phase II design a limit?
Without a placebo group, a slower PSA rise could come from chance, the disease or the treatment already given.
A phase II study asks whether an idea is worth a bigger test. It is not meant to prove the idea. The first study had one group, so everyone got pomegranate, and there was no one to compare with (Pantuck et al., Clin Cancer Res 2006).
The second study tried two extract doses, 1 g and 3 g a day, in 104 men, again without placebo. Doubling time rose from 11.9 to 18.5 months, and the authors called the meaning unclear (Paller et al., Prostate Cancer Prostatic Dis 2013). Of the men, 42% left before the end, mostly because PSA kept rising.
| Study | What was given | Design | Finding |
|---|---|---|---|
| Juice study (Pantuck et al., Clin Cancer Res 2006) | 8 oz of juice a day | One group, no placebo | Doubling time 15 to 54 months |
| Extract study (Paller et al., Prostate Cancer Prostatic Dis 2013) | Extract, 1 g or 3 g a day | Two doses, no placebo, 104 men | 11.9 to 18.5 months; testosterone unchanged |
Pomegranate
Men with rising PSA after cancer treatment; no placebo group in either.
Bars compare study doses or official limits with each other, not with Prostadine: its amounts are not printed, so its bar stays empty. No trial has tested Prostadine itself.
Testosterone04
Does pomegranate raise testosterone?
No evidence says it does. The extract trial found no significant change in testosterone.
The sales page says pomegranate "Supports testosterone levels" (Prostadine sales page). The one trial we found that measured the hormone saw no meaningful change at either dose (Paller et al., Prostate Cancer Prostatic Dis 2013).
Testosterone does drift down with age, about 1% a year for total testosterone, with wide differences between men (Feldman et al., MMAS, JCEM 2002). Roughly 20% of men over 60 have low levels by one measure (Harman et al., BLSA, JCEM 2001). Low levels are a lab diagnosis, not something to guess at with a supplement.
A review of popular testosterone-booster products found no definitive evidence they work, and fewer than one in five of the studies behind their ingredients involved people (Balasubramanian et al., J Sex Med 2019). If you suspect low testosterone, ask your doctor for a blood test.
Form05
Is pomegranate extract the same as juice?
No. Juice is the pressed fruit, while an extract is concentrated, and the two can differ a lot in what they contain.
Prostadine does not say what kind of extract it uses, how it was standardized or how much goes into 2 ml. The studies above used 8 ounces of juice and 1 to 3 grams of a named extract, amounts a small dropper dose is unlikely to match, though we cannot confirm that without the label.
This is the same gap that runs through all nine ingredients. A named plant on a sales page tells you what is claimed, and the Supplement Facts panel would tell you how much. See the label page.
Prostadine: from $49 a bottle2 fl oz (60 mL) dropper · 2, 3 or 6 bottles · 60-day money-back guarantee
See packsMedicines06
Does pomegranate interact with medicines?
Possibly. Pomegranate juice may change how the liver and gut handle some drugs.
A review says pomegranate compounds inhibit the enzymes CYP3A4 and CYP2C9, which process many medicines (Mansoor et al., Molecules 2023). Observational reports described juice prolonging the effect of warfarin and sildenafil. The real-world size of this is unproven, and the review covered juice, not drops.
- On warfarin or another blood thinner? Ask first.
- On sildenafil, tadalafil or a nitrate? Ask first.
- Heading into surgery? Tell the surgical team about every supplement (FDA 101: Dietary Supplements).
Do not stop or change a prescription because of a supplement. Show your doctor or pharmacist the Prostadine bottle.
Blood flow07
Can pomegranate extract affect blood pressure or blood flow?
The sources we read do not test it. The "healthy blood flow" claim has no study behind it on the sales page.
The page says pomegranate "Maintains healthy blood flow", with no citation (Prostadine sales page). The studies in this review measured PSA and testosterone, not blood pressure. We found no figure on pressure to quote, and we will not invent one.
If you take blood pressure medicine, the interaction note above is the safe starting point. Report dizziness or a pounding heart to your doctor.
Seek same-day care if you cannot pass urine at all, see blood in it, have fever or chills with painful urination, or have severe belly, back or side pain (NIDDK, Prostatitis).
Verdict08
Should pomegranate change your decision about Prostadine?
Pomegranate is a reasonable fruit with interesting early research, in a different group of men. It is not a reason to expect help for BPH or a lift in testosterone.
Compare it with the herb on the saw palmetto page and read the claims on the benefits page. New urinary symptoms deserve an exam, per prostate basics.
FAQ09
Pomegranate questions, short answers
What does pomegranate extract do for the prostate?
No trial shows it does anything for BPH. The studies tested juice or extract in men with rising PSA after cancer treatment, without placebo groups (Pantuck et al., Clin Cancer Res 2006) (Paller et al., Prostate Cancer Prostatic Dis 2013). Prostadine's sales page claims only blood flow and testosterone support for it (Prostadine sales page).
What did the PSA doubling-time study find?
In men with rising PSA after cancer treatment, daily juice went with a PSA doubling time that grew from 15 to 54 months. There was no placebo group, and the authors said the result warrants further testing (Pantuck et al., Clin Cancer Res 2006).
Does pomegranate raise testosterone?
No evidence says it does. In a 104-man trial of 1 g or 3 g of extract a day, testosterone did not change significantly (Paller et al., Prostate Cancer Prostatic Dis 2013). The sales page's "Supports testosterone levels" claim names no study (Prostadine sales page).
Is pomegranate extract the same as juice?
No. Juice is the pressed fruit, while extract is concentrated. The first PSA study used juice and the second a named extract (Pantuck et al., Clin Cancer Res 2006) (Paller et al., Prostate Cancer Prostatic Dis 2013). Prostadine does not print its extract type or amount, so neither study matches it.
Does pomegranate interact with medicines?
It may. Pomegranate juice inhibits the CYP3A4 and CYP2C9 enzymes, and reports link it with longer warfarin and sildenafil effects, though the real size is unproven (Mansoor et al., Molecules 2023). Ask your pharmacist if you take either drug.
Can pomegranate extract affect blood pressure?
The sources we read did not measure it, so we cannot say. The sales page claims it "Maintains healthy blood flow" without a study (Prostadine sales page). If you take blood pressure medicine, ask your doctor before starting Prostadine.
Why is the uncontrolled phase II design a limit?
With no placebo group, a slower PSA rise could be chance, the disease course or earlier treatment. A phase II study only asks if an idea merits a bigger test, and both authors asked for placebo-controlled trials (Pantuck et al., Clin Cancer Res 2006) (Paller et al., Prostate Cancer Prostatic Dis 2013).
Who wrote this10
Written and reviewed by
Pages built from the bottle front, the sales page and linked NIH, FDA, FTC and peer-reviewed sources.
Last updated . See our editorial standards and how we check reviews. This website is run by Goprostadine, a USA Authorized Prostadine Retailer, not by the manufacturer. We are paid when you buy through our order links.
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